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論文題目 MAnorm2 for quantitatively comparing groups of ChIP-seq samples
作者 Tu, Shiqi; Li, Mushan; Chen, Haojie; Tian, Fengxiang; Xu, Jian; Waxman, David J.; Zhang, Yijing; Shao, Zhen
聯系作者 Shao, Z
發表年度 2021
刊物名稱 GENOME RESEARCH
31
1
頁碼 131-145
摘要 Eukaryotic gene transcription is regulated by a large cohort of chromatin-associated proteins, and inferring their differential binding sites between cellular contexts requires a rigorous comparison of the corresponding ChIP-seq data. We present MAnorm2, a new computational tool for quantitatively comparing groups of ChIP-seq samples. MAnorm2 uses a hierarchical strategy for normalization of ChIP-seq data and assesses within-group variability of ChIP-seq signals based on an empirical Bayes framework. In this framework, MAnorm2 allows for abundant differential ChIP-seq signals between groups of samples as well as very different global within-group variability between groups. Using a number of real ChIP-seq data sets, we observed that MAnorm2 clearly outperformed existing tools for differential ChIP-seq analysis, especially when the groups of samples being compared had distinct global within-group variability.
學科 Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Genetics & Heredity
影響因子 11.093
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